Wenger’s side lost their last match against Leicester City but will be hoping to send their long-serving manager out on a high by winning their first away game of 2018.
The Gunners haven’t recorded a victory away from home in the current calendar year, the worst record of any team in English football, and face a Huddersfield side who are in confident form following draws against Manchester City and Chelsea.
Laurent Koscielny will miss the World Cup with a suspected ruptured Achilles sustained in the first half of Arsenal’s Europa League semi-final defeat to Atletico Madrid.
Egypt midfielder Mohamed Elneny is out with ankle ligament damage and is unlikely to be involved while a back problem has ruled out Mesut Ozil for the final game.
Spanish midfielder Santi Cazorla remains a long-term absentee with an Achilles injury, although he is running again and will hope to be involved in pre-season if his contract gets renewed.