The summer of 2013 and 2014 saw Arsene Wenger signed top players from the La Liga.
The Gunners have been trying for months to tie their star duo down to new deals at the Emirates Stadium, but have not made any progress and may now find it even harder to convince them to stay.
Bayern Munich steamrollered Arsenal 10-2 on aggregate as they dumped them out of the Champions League at the last-16 stage once again, and reports suggest that could end up being the last straw for Sanchez and Ozil.
Arsenal have been heavily reliant on both players this season and look likely to be in big trouble if both of them walk away, with the Daily Mirror claiming that Paris Saint-Germain are in pole position to land Sanchez.
Ozil, meanwhile, has been linked with a return to Germany after his international team-mate Jerome Boateng hinted at luring him to Bayern by recently saying: ‘I love to play with him.’
Arsenal’s failure to deliver major trophies since moving to the Emirates from Highbury in 2006 has constantly seen them lose their biggest names, and it looks like Sanchez and Ozil will be next after the club’s latest humiliation.